Guerrero auditioned for a role on Devious Maids, but ended up with a role on Orange is the New Black, where she plays a Bronx-bred character that is likely Puerto Rican. She has had a recurring role on Are We There Yet?. In 2014, she appeared in Emoticon ;), a comedy about a May–December romance in which her father is involved with a doctoral candidate. Guerrero was a cast in a regular role on season 2 of CBS show Superior Donuts. Guerrero currently portrays Crazy Jane on Doom Patrol.
|2019—present||Doom Patrol||Crazy Jane||Main role|
|2018–2019||Elena of Avalor||Vestia (voice)|
|2017-2018||Superior Donuts||Sofia||21 episodes|
|2014-2019||Jane the Virgin||Lina Santillan|| Recurring role|
|2013—2019||Orange Is the New Black||Maritza Ramos||Recurring role|
|2014||Taxi Brooklyn||Carmen Lopez||"Brooklyn Heights" (102)|
|2013||Pushing Dreams||Lynette Melendez|
|2013||Person of Interest||Ashley||"Liberty" (301)|
|2013||Blue Bloods||Carmen||"This Way Out" (323)|
|2012||Are We There Yet?||Stacey||"The Cooking Episode"|
"The Life Insurance Episode"
"The Thanksgiving Episode"
"The Wrong Way Episode"
|2011||Body of Proof||Sara Gonzales||"Buried Secrets"|
|2016||Happy Yummy Chicken||Cheryl Davis|
|2014||Peter and John||Lucia|
|2014||My Man Is a Loser||Malea|
|2014||Emoticon ;)||Amanda Nevins|
|2012||Saved by the Pole||Princess||short|
|2011||Festival||Ivan Model 2|