Tesfai has appeared in Wicked Wicked Games (2006), Melrose Place (2009) and Franklin & Bash. She is also the founder of jewelry company Fortuned Culture, of which the proceeds go to charity. Following her turn on Jane the Virgin, Tesfai has appeared on Silicon Valley, Rosewood and Superstore. In 2019, Tesfai started appearing in a recurring role on CW superhero series Supergirl, as James Olsen's sister, Kelly Olsen. In March 2019, she was promoted to a series regular for Season 5.
- Tesfai is Ethiopian on her mother's side
- Tesfai is best friends with Bridget Regan (Sin Rostro), Yael Grobglas (Petra/Anežka Archuletta), Yara Martinez (Luisa Alver) and Andrea Navedo (Xiomara De La Vega)